Clinical trials
Since POETIC's inception, two first-in-child clinical trials have been conducted increasing early access to novel molecularly targeted agents for treatment of children and adolescents with refractory malignancies after completion of adult Phase I studies. One of the studies resulted in evidence of clinical benefit in patients with tumors of the central nervous system using a novel agent targeting the epidermal growth factor receptor, cetuximab. These findings have provided the scientific rationale for a Phase II study targeting high grade central nervous system tumors, which is on-going.
Active clinical trials
Carfilzomib in combination with Cyclophosphamide and Etoposide for children
A Phase I study of Carfilzomib in combination With Cyclophosphamide and Etoposide for children with relapsed and refractory solid tumors and leukemias
Sponsor: Amgen
Protocol: POE14-01
Principal investigator: Jessica Boklan, MD
Site: Phoenix Children's Hospital
Estimated accrual years: 2.0
Read more about this trial at ClinicalTrials.gov
Idasanutlin in combination with either chemotherapy or Venetoclax in the treatment of pediatric and young patients with relapsed/refractory acute leukemias or solid tumors
Sponsor: Genentech
Protocol: GO40871
Estimated accrual years: 5 years (in 3 phases)
Read more about this trial at ClinicalTrials.gov
Safety and dose finding study of Neratinib in children and young adults with cancer that has returned or not responded to treatment
A Phase I/II study of Neratinib in pediatric patients with relapsed or refractory solid tumors or hematologic malignancies
Sponsor: Puma
Protocol: POE16-01
Principal investigator: Tanya Trippett, MD
Site: Memorial Sloan Kettering Cancer Center
Estimated accrual years: 1.0 (Phase I); 1.5 (Phase II)
Read more about this trial at ClinicalTrials.gov
PARPAML: A Phase 1 Protocol for Relapsed Pediatric AML to Determine the Safety and Efficacy of the PARP Inhibitor Talazoparib in Combination with Chemotherapy
Sponsor: Dr. Kamens
Protocol: POE22-01
Principal investigator: Jennifer Kamens, MD
Site: Stanford University
Estimated accrual years: 2.0
Read more about this trial at ClinicalTrials.gov
Completed studies
- Safety and pharmacokinetics of Cobimetinib in pediatric and young adult participants with previously treated solid tumors
- Cyclophosphamide, Topotecan, and Bevacizumab (CTB) in patients with relapsed/refractory Ewing's Sarcoma and Neuroblastoma
- Clinical study of Vorinostat in combination with Etoposide in pediatric patients < 21 years at diagnosis with refractory solid tumors
- External beam radiation therapy and Cetuximab followed by Irinotecan and Cetuximab for children and young adults with newly diagnosed diffuse pontine tumors and high-grade astrocytomas
- Everolimus (RAD001) for children with chemotherapy-refractory progressive or recurrent low-grade gliomas
- Plerixafor as a chemosensitizing agent for relapsed acute leukemia and MDS in pediatric patients
- Phase I trial of Anti-PD-L1 in patients with solid tumors
- Phase I trial of Cabazitaxel in patients with solid tumors including CNS
- Phase I trial of Cabazitaxel in patients with solid tumors including CNS
- Phase I trial of 17-AAG in patients with solid tumors and leukemia
- Phase I trial of Cetuximab and Irinotecan in patients with solid tumors including CNS
- Phase I trial of Oxaliplatin, Fluorouracil, and Leucovorin in patients with solid tumors
- Phase I trial of Clofarabine and Cyclophosphamide in patients with leukemia
- Phase I trial of Ridaforolimus in patients with solid tumors
- Safety and pharmacokinetics of Atezolisumb (MPDL3280A) in pediatric and young adults patients with previously treated solid tumors
Programs
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