The story of a child with an incurable cancer symbolizes the tasks as well as the great opportunities presented by modern medicine. Our overall objective is to facilitate an environment that will bring together the finest minds in pediatric oncology to provide the best care possible for our children and their families. Admittedly, the numbers of children that require new treatments are a small but the return for addressing their issues is big because of the emotional burden on the families and the cost to society in terms of productive years lost. Importantly, understanding the biology of relapse would also inform us a great deal about the mechanisms of cancer and help to discover future treatments. To facilitate the success of such a program, we focus on strengthening current and new translational research in strategic areas identified through consultation with the wider pediatric oncology community. These include novel immune based medications and precision therapeutics. Our overall vision is to provide new treatments through innovative research, international collaborations and industry partnerships. Central to this objective is the building of an infrastructure that would solidify the efforts on research and development of novel therapeutics through effective multi-institutional clinical trials.